HelixlyAI Genome Report Prepared for Sample Subject
Report ID HX-2026-0042 · synthetic
Immunity & Allergy · Document 17 of 24

Autoimmune Markers

Selected variants associated with Sample Subject's autoimmune predisposition, read from the PTPN22 and CTLA4 immune-regulatory genes. All values below are synthetic and for demonstration only.

2 findings 1 Tier 2 1 Tier 3 Reviewed 2026-01-15

Provenance

Data Provenance verified chain
Document
Autoimmune Markers
Source assembly
GRCh37 (hg19)
Source file SHA-256
0000a1b2c3d4e5f6…4b5c6d7e
Supersedes
prior v1 · SHA 1111f0e9…
Evidence sources
ClinVar, PubMed, dbSNP
Access date
2026-01-15

Per-Gene Findings

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PTPN22 — R620W Risk Allele

Protein tyrosine phosphatase · T-cell signaling
ClinVarTier 2
rs2476601 1:114,377,568 GA

The GA genotype carries one PTPN22 R620W risk allele. This variant alters T-cell receptor signaling and associates with several autoimmune conditions across populations.

Source: ClinVar PTPN22 R620W ↗ · PubMed PMID 15004560 ↗

CTLA4 — Checkpoint Locus

Cytotoxic T-lymphocyte antigen 4 · immune checkpoint
GWASTier 3
rs3087243 2:204,738,919 GA

The GA genotype sits at the CTLA4 checkpoint locus. CTLA4 restrains T-cell activation, and this position contributes to autoimmune-susceptibility context.

Source: GWAS Catalog CTLA4 ↗ · dbSNP rs3087243 ↗

Genotype Table

Variants evaluated in this document — synthetic
rsIDchr:posGenotypeGeneSignificance
rs24766011:114,377,568GAPTPN22Tier 2
rs30872432:204,738,919GACTLA4Tier 3
Consult your prescribing clinician. This HelixlyAI report is a synthetic demonstration generated from a consumer DNA export. It is not a diagnosis, prescription, or substitute for professional medical advice. Do not start, stop, or change any medication based on this document. Genotype is one of many factors influencing drug response.